What is AOD?
AOD is a peptide fragment of the C- terminus of Human Growth Hormone to which a tyrosine, one of the 20 standard amino acids used to synthesize proteins, is added at the end or to the N – terminal of the peptide. Like Growth Hormone, AOD has been shown in studies to stimulate the break down or destruction of fat and prevent the transformation of fatty food materials into body fat. Recent clinical studies have shown that AOD did show a reduction of body fat in the stomach area in obese, overweight, and average built people. AOD works by mimicking the way Growth Hormone regulates fat metabolism, but without the bad effects on blood sugar or growth that is seen with unmodified Growth Hormone.
What is HA?
HA stands for Hyaluronic Acid. HA has intra-articular, cosmetic, and topical uses. Cosmetically, it is used to treat wrinkles. Topically, it is used for the management of ulcers, cuts, abrasions, donor sites, burns, and postoperative incisions.
How does AOD + HA work?
Results from studies suggest that co-injection of intra-articular HA and a recombinant human growth hormone is more effective than HA injections alone in osteoarthritis model. Osteoarthritis (OA) is a degenerative joint disease characterized by progressive articular cartilage loss, subchondral bone sclerosis, osteophyte formation, synovial membrane changes, and an increased synovial fluid with decreased viscosity and lubrication properties. HA has been recognized as a safe and effective alternative therapy. It binds to the proteoglycan surface components of articular cartilage, provides an important boundary layer for lubrication, prevents cartilage destruction, influences anti-inflammatory properties, and facilitates cartilage rearrangement. The effectiveness of HA therapy is dependent on OA type. While moderate to mild OA is responsive to Hyaluronic Acid, it is not effective in cases in individuals with significant architectural changes.
Growth hormone, like AOD, is an important regulator of skeletal growth and bone mineral density. It also stimulates cartilage growth, probably through local and systemic insulin-like growth factor 1 (IGF-1) production and possibly by direct stimulation of cartilage cell proliferation. Circulating growth hormone, or its mediators, may accelerate osteochondral defect healing by stimulating bone and cartilage tissue formation.
When AOD and HA are combined they are an effective treatment in helping to repair cartilage in any intra-articular space. It’s thought to activate the body’s own stem cells that are found in fat tissue. We have found that doctors have experienced similar results to Prolotherapy.
No serious adverse reactions have been seen as of yet, unless the patient is allergic. If you prove to be allergic, intermittent swelling and severe inflammation that can evolve into abscesses can happen.